Overview

Overview

N8 Medical, LLC, a clinical-stage medical device company, is at the forefront of commercializing innovative medical devices enhanced with a novel class of active compounds known as Ceragenins.

N8 Medical’s goal is to revolutionize the safety of indwelling medical devices and implants. By applying our innovative CeraShield coating to these devices, we aim to prevent Hospital-Acquired Infections (HAIs), thereby reducing the reliance on antibiotics and combating Antimicrobial Resistance (AMR).

As an integral part of N8 Biosciences, a holding company committed to the extensive application of Ceragenins, N8 Biosciences is making strides in two key areas :

The Company’s proprietary technology is based on Dr. Paul B. Savage’s research and invention at Brigham Young University (BYU).

What sets our Ceragenins apart? These synthetic molecules are designed to mimic endogenous host defense peptides – nature’s own way of combating pathogens. They replicate the multifaceted activities of natural antimicrobial peptides, but with enhanced stability and manufacturability. Unlike peptides, Ceragenins resist proteolytic degradation and can be produced on a large scale, making them a practical solution for widespread use.

Here's why Ceragenins are groundbreaking :

The Health Economics Of Infections

AMR

The next pandemic is already here

Leading Infectious Disease experts have labeled the crisis of Antimicrobial Resistant (AMR) Infections as “The Silent Pandemic.”
One factor that is inextricably linked to, and exacerbates antibiotic resistance has been consistently overlooked to date; this factor is biofilm.

Biofilm fouling of medical devices account for approximately 65% of HAIs.

In 2001, Dr. Bell, Deputy Director of CDC′s Division of Healthcare Quality Promotion, authored a seminal article “Biofilms: A Clinical Perspective” in which he said:
A fundamental shift is needed in our approach to patient care and infectious diseases if we are to prevent device-associated infections, treatment failures, and undesired consequences (e.g. selection for antimicrobial-resistant bacterial strains) due to biofilm-related infections.
Ignaz_Semmelweis_1858

DR.I.Semmelweis

In the mid-19th century, Ignaz Semmelweis, a Hungarian physician, made a groundbreaking discovery at the Vienna General Hospital. Confronted with high mortality rates in the maternity ward, Semmelweis observed a critical difference between two wards: one staffed by doctors and medical students and the other by midwives. The former had significantly higher infection rates and fatalities among new mothers.

Semmelweis traced the root cause to the doctors and students who, unlike the midwives, conducted autopsies and then attended childbirths without washing their hands. His solution was simple yet revolutionary for the time: mandatory handwashing with a chlorine solution  for all medical staff before examining patients. This intervention drastically reduced the incidence of puerperal fever, a common and often fatal infection.

The present fight against Hospital-Acquired Infections (HAIs) and AMR echoes the challenges faced by Dr. Semmelweis. Today we have technology available to be applied as antimicrobial coating of medical devices. This approach is analogous to Semmelweis’s handwashing protocol, serving as a critical barrier against infections.

N8 Medical’s goal is to revolutionize the safety of indwelling medical devices and implants. By applying our innovative CeraShield coating to these devices, we aim to prevent Hospital-Acquired Infections (HAIs), thereby reducing the reliance on antibiotics and combating Antimicrobial Resistance (AMR).

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N8 Medical, Inc. (N8 Medical) is a clinical-stage medical device company focused on commercializing medical devices that incorporate a novel class of active compounds called ceragenins.The subsidiaries for N8 Medical Inc are N8 Medical, LLC for Medical Device Development and Kinnear Pharmaceuticals, LLC for drug development.