Ceragenins are synthetic molecules modeled after host defense peptides, vital components of our innate immune system. Ceragenins mimic and enhances LL-37, reduce and inhibit IL-6, without creating antimicrobial resistance.
Science
Ceragenins: A Synthesis of Nature and Innovation
Inspired By Nature
Unique capabilities
They exhibit an array of pharmacological activities, including antimicrobial and anti-inflammatory effects, similar to their natural counterparts.
Unique capabilities
Backed by extensive research (Since 2019 there have been 350 peer-reviewed journal articles about the Ceragenins technology), patents, and significant investments, Ceragenins are a breakthrough in medical science.
Proven And Patented
Structure
Featuring a sterol backbone adorned with amino acids and other groups, they have a positive charge that targets the negatively charged cell membranes of many pathogens.
LL37- Little peptide, big effects
- LL-37 is the only human member of the cathelicidin family of antimicrobial peptides.
- A potent antimicrobial peptide with a broad activity spectrum. Effective against various bacteria, fungi, and lipid-enveloped viruses.
- LL-37 is a natural first line defense against infection invasion of pathogens while promoting accelerated wound healing.
- LL-37 is active against drug-resistant organisms & biofilms.
Potent Antimicrobials: Beyond Conventional Approaches
- Targeting membranes : Ceragenins disrupt microbial cell membranes rather than internal replication mechanisms, ensuring efficacy against a broad spectrum of pathogens.
- Combatting biofilms : Exceptional in preventing and eradicating resistant bacterial and fungal biofilms, unlike standard antibiotics.
- CSAs stand out with rapid, potent action against formidable pathogens, including MRSA and Pseudomonas.
Strong Anti-Inflammatory and Immunomodulatory Activities
- Mimicking natural peptides : Ceragenins parallel the properties of cathelicidin antimicrobial peptides in immune modulation.
- Diverse effects : They influence key cytokines (IL-6, TNF alpha), promote chemokine expression, and play roles in angiogenesis, apoptosis, and wound healing.
- Bacterial Resistance : A Minimal Concern. Ceragenins have minimal resistance potential due to their novel mechanism of action. Serial passaging studies (30x) show no mutational resistance and recent proteomics data shows that CSAs unique mechanism of action targets key components of conserved features of bacterial membranes.
- Novel action : Ceragenins’ unique approach minimizes the likelihood of bacterial resistance, supported by extensive passaging studies and proteomic data.
- Targeting bacterial membranes : Their mechanism disrupts conserved features of bacterial cell walls, a strategy less prone to resistance development.
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- info@n8medical.com
- N8 Medical, LLC1090 Center DrivePark City, UT 84098
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N8 Medical, Inc. (N8 Medical) is a clinical-stage medical device company focused on commercializing medical devices that incorporate a novel class of active compounds called ceragenins.The subsidiaries for N8 Medical Inc are N8 Medical, LLC for Medical Device Development and Kinnear Pharmaceuticals, LLC for drug development.