new-publications

Publications

Publications

Direct links to select peer-reviewed journal articles regarding ceragenins can be found below:

Direct links to select peer-reviewed journal articles regarding ceragenins can be found below:

  • Ceragenins are active against drug-resistant Candida auris clinical isolates in planktonic and biofilm forms. 

Marjan M. Hashemi, John Rovig, Brett S. Holden, Maddison F. Taylor, Scott Weber, John Wilson, Brian Hilton, Aaron L. Zaugg, Samuel W. Ellis, Connor D. Yost, Patrick M. Finnegan, Charles K. Kistler, Elizabeth L. Berkow, Shenglou Deng, Shawn R. Lockhart, Marnie Peterson and Paul B. Savage (2018).

Marjan M. Hashemi, John Rovig, Jordan Bateman, Brett S. Holden, Tomasz Modelzelewski, Iliana Gueorguieva, Martin von Dyck, Ronald Bracken, Carl Genberg, Shenglou Deng and Paul B. Savage (2017).

  • Candidacidal Activity of Selected Ceragenins and Human Cathelicidin LL-37 in Experimental Settings Mimicking Infection Sites.

Bonita Durnaś, Urszula Wnorowska, Katarzyna Pogoda, Piotr Deptuła, Marzena Wątek, Ewelina Piktel, Stanisław Głuszek, Xiaobo Gu, Paul B. Savage, Katarzyna Niemirowicz, Robert Bucki (2016).

Robert Bucki, Katarzyna Niemirowicz, Urszula Wnorowska, Fitzroy J. Byfield, Ewelina Piktel, Marzena Watek, Paul A. Janmey, Paul B. Savage (2015).

  • CSA-131, a ceragenin active against colistin-resistant Acinetobacter baumannii and Pseudomonas aeruginosa clinical isolates.

Xavier Vila-Farrés, Anna Elena Callarisa, Xiaobo Gu, Paul B. Savage, Ernest Giralt, Jordi Vila (2015).

Urszula Wnorowska, Katarzyna Niemirowicz, Melissa Myint, Scott L. Diamond, Marta Wróblewska, Paul B. Savage, Paul A. Janmey, Robert Bucki (2015).

  • Local Delivery of the Cationic Steroid Antibiotic CSA-90 Enables Osseous Union in a Rat Open Fracture Model of Staphylococcus aureus Infection.

Aaron Schindeler, PhD, Nicole Y.C. Yu, PhD, Tegan L. Cheng, BE/BMedSci, Kate Sullivan, PhD, Kathy Mikulec, Lauren Peacock, Ross Matthews, BVSc, Dip Vet Clin Path, and David G. Little, FRACS(Orth), PhD (2015).

Urszula Surel, Katarzyna Niemirowicz, Michal Marzec, Paul B. Savage, Robert Bucki (2014).

  • In Vitro Bactericidal and Bacteriolytic Activity of Ceragenin CSA-13 against Planktonic Cultures and Biofilms of Streptococcus pneumoniae and Other Pathogenic Streptococci.

Miriam Moscoso, María Esteban-Torres, Margarita Menéndez, Ernesto García (2014).

Xiaobo Gu, Jacob D. Jennings, Jason Snarr, Vinod Chaudhary, Jacob E. Pollard, and Paul B. Savage (2013).

Carole Nagant, Betsey Pitts, Philip S. Stewart, Yanshu Feng, Paul B. Savage & Jean-Paul Dehaye (2013).

  • In vivo efficacy of a silicone‒cationic steroid antimicrobial coating to prevent implant-related infection.

Dustin L. Williams, Bryan S. Haymond, James P. Beck, Paul B. Savage, Vinod Chaudhary, Richard T. Epperson, Brooke Kawaguchi, Roy D. Bloebaum (2012).

C. Nagant, Y. Feng, B. Lucas, K. Braeckmans, P. Savage, J.P. Dehaye (2011).

  • In vivo efficacy of a silicone‒cationic steroid antimicrobial coating to prevent implant-related infection.

Michael D. Howell, Joanne E. Streib, Byung Eui Kim, Leighann J. Lesley, Annegret P. Dunlap, Dianliang Geng, Yanshu Feng, Paul B. Savage and Donald Y.M. Leung (2009).

Judy N. Chin, Michael J. Rybak, Chrissy M. Cheung, and Paul B. Savage (2007).

Ceragenins are Highly Effective Against Antimicrobial-Resistant Pathogens:

Ceragenins are Highly Effective Against Antimicrobial-Resistant Pathogens:

Paprocka P, Mańkowska A, Skłodowski K, Król G, Wollny T, Lesiak A, Głuszek K, Savage PB, Durnaś B, Bucki R (2022).

  • Ceragenins and Antimicrobial Peptides Kill Bacteria through Distinct Mechanisms.

Mitchell G, Silvis MR, Talkington KC, Budzik JM, Dodd CE, Paluba JM, Oki EA, Trotta KL, Licht DJ, Jimenez-Morales D, Chou S, Savage PB, Gross CA, Marletta MA, Cox JS (2022).

Damar-Çelik D, Mataracı-Kara E, Savage PB, Özbek-Çelik B (2020).

  • NDM-1 Carbapenemase-Producing Enterobacteriaceae are Highly Susceptible to Ceragenins CSA-13, CSA-44, and CSA-131.

Chmielewska SJ, Skłodowski K, Piktel E, Suprewicz Ł, Fiedoruk K, Daniluk T, Wolak P, Savage PB, Bucki R (2020).

 Paprocka P, Durnaś B, Mańkowska A, Skłodowski K, Król G, Zakrzewska M, Czarnowski M, Kot P, Fortunka K, Góźdź S, Savage PB, Bucki R (2021)

  • Candidacidal Activity of Selected Ceragenins and Human Cathelicidin LL-37 in Experimental Settings Mimicking Infection Sites.

Durnaś B, Wnorowska U, Pogoda K, Deptuła P, Wątek M, Piktel E, Głuszek S, Gu X, Savage PB, Niemirowicz K, Bucki R (2016).

Bozkurt-Guzel C, Inci G, Oyardi O, Savage PB (2020).

  • Proteomic Analysis of Resistance of Gram-Negative Bacteria to Chlorhexidine and Impacts on Susceptibility to Colistin, Antimicrobial Peptides, and Ceragenins.

Hashemi MM, Holden BS, Coburn J, Taylor MF, Weber S, Hilton B, Zaugg AL, McEwan C, Carson R, Andersen JL, Price JC, Deng S, Savage PB (2019).

Wnorowska U, Niemirowicz K, Myint M, Diamond SL, Wróblewska M, Savage PB, Janmey PA, Bucki R (2015).

  • Comparative In Vitro Activities of First and Second-Generation Ceragenins Alone and in Combination with Antibiotics Against Multidrug-Resistant Klebsiella pneumoniae Strains.

Ozbek-Celik B, Damar-Celik D, Mataraci-Kara E, Bozkurt-Guzel C, Savage PB (2019).

Bozkurt Güzel Ç, Avci NM, Savage P (2020).

  • CSA-131, a ceragenin active against colistin-resistant Acinetobacter baumannii and Pseudomonas aeruginosa clinical isolates.

Xavier Vila-Farrés, Anna Elena Callarisa, Xiaobo Gu, Paul B. Savage, Ernest Giralt, Jordi Vila. (2015).

Marjan M Hashemi, John Rovig, Brett S Holden, Maddison F Taylor, Scott Weber, John Wilson, Brian Hilton, Aaron L Zaugg, Samuel W Ellis, Connor D Yost, Patrick M Finnegan, Charles K Kistler, Elizabeth L Berkow, Shenglou Deng, Shawn R Lockhart, Marnie Peterson, Paul B Savage (2018).

  • Endotracheal tubes coated with a broad-spectrum antibacterial ceragenin reduce bacterial biofilm in an in vitro bench top model.

María Consuelo Latorre, María Jesús Pérez-Granda, Paul B Savage, Beatriz Alonso, Pablo Martín-Rabadán, Rafael Samaniego, Emilio Bouza, Patricia Muñoz, María Guembe (2021).

Direct links to select articles relevant to the ceragenin technology and N8 Medical’s products under development can be found below:

European Commission (2016)

  • The interconnection between biofilm formation and horizontal gene transfer.

onas Stenløkke Madsen, Mette Burmølle, Lars Hestbjerg Hansen, Søren Johannes Sørensen (2012).

Karen B. Zur, MD, David L. Mandell, MD, Ronald E. Gordon, PHD, Ian Holzman, MD, and Michael A. Rothschild, MD (2004).

  • Biofilms and device-associated infections.

Rodney M. Donlan (2001).

Policy Documents

Contact us

Lets Get in Touch!

Follow now

mynewform

Basic contact form

N8 Medical, Inc. (N8 Medical) is a clinical-stage medical device company focused on commercializing medical devices that incorporate a novel class of active compounds called ceragenins.The subsidiaries for N8 Medical Inc are N8 Medical, LLC for Medical Device Development and Kinnear Pharmaceuticals, LLC for drug development.